PT - JOURNAL ARTICLE AU - GIANLUCA FERINI AU - ANTONELLA TRIPOLI AU - LAURA MOLINO AU - ALBERTO CACCIOLA AU - SARA LILLO AU - SILVANA PARISI AU - VINCENZA UMINA AU - SALVATORE IVAN ILLARI AU - VALENTINA ANNA MARCHESE AU - IRENE RITA CRAVAGNO AU - GIUSEPPINA RITA BORZÌ AU - VITO VALENTI TI - How Much Daily Image-guided Volumetric Modulated Arc Therapy Is Useful for Proctitis Prevention With Respect to Static Intensity Modulated Radiotherapy Supported by Topical Medications Among Localized Prostate Cancer Patients? AID - 10.21873/anticanres.14981 DP - 2021 Apr 01 TA - Anticancer Research PG - 2101--2110 VI - 41 IP - 4 4099 - http://ar.iiarjournals.org/content/41/4/2101.short 4100 - http://ar.iiarjournals.org/content/41/4/2101.full SO - Anticancer Res2021 Apr 01; 41 AB - Background/Aim: To evaluate if topical support therapy during static-intensity modulated radiotherapy (sIMRT) course is able to equal the characteristic minimum risk for radiation proctitis of Image-guided volumetric modulated arc therapy (IG-VMAT) treatment among localized prostate cancer patients. Patients and Methods: Rectal toxicity data of the above patients were retrospectively collected throughout three different clinical periods at our Radiotherapy Deparment: from October 2011 to December 2012, prostate cancer patients were treated with sIMRT and in advance supported by means of daily topical corticosteroids; from January 2013 to November 2016, topical corticosteroids were replaced by daily hyaluronic acid enemas; from December 2016 to May 2018 eligible patients were treated with newly introduced IG-VMAT supported by only on-demand topical corticosteroids. Results: Among 359 eligible patients, IG-VMAT was proven generally more effective than sIMRT supported by topical medications in terms of proctitis reduction, although without clinical and practical relevance. Conclusion: Topical medications might have a role in radiation proctitis prevention.