TY - JOUR T1 - Analysis of the Response and Toxicity to Gefitinib of Non-small Cell Lung Cancer JF - Anticancer Research JO - Anticancer Res SP - 435 LP - 441 VL - 25 IS - 1B AU - JUN KONISHI AU - KOICHI YAMAZAKI AU - ICHIRO KINOSHITA AU - HIROSHI ISOBE AU - SHIGEAKI OGURA AU - SATOKO SEKINE AU - TAKASHI ISHIDA AU - RIOU TAKASHIMA AU - MEGUMI NAKADATE AU - SHYU NISHIKAWA AU - TAKESHI HATTORI AU - HAJIME ASAHINA AU - MIKADO IMURA AU - EIKI KIKUCHI AU - JUNKO KIKUCHI AU - NAOFUMI SHINAGAWA AU - HIROSHI YOKOUCHI AU - MITSURU MUNAKATA AU - HIROTOSHI DOSAKA-AKITA AU - MASAHARU NISHIMURA Y1 - 2005/01/01 UR - http://ar.iiarjournals.org/content/25/1B/435.abstract N2 - Background: Gefitinib is an oral agent that inhibits the tyrosine kinase of epidermal growth factor receptor (EGFR), which had antitumor activity in patients with previously treated non-small cell lung cancer (NSCLC). We analyzed the efficacy, toxicity and overall survival time of gefitinib treatment in patients with NSCLC. Patients and Methods: One hundred and twenty-two patients with NSCLC, who received gefitinib between 2002 and 2004 in our institutes, were evaluated retrospectively. Results: The objective response rate was 24.6%. The variables identified as significant in univariate analysis included gender and smoking habit. The median overall survival time was 14.4 months. Significant variables associated with improved survival included good performance status (PS), female, adenocarcinoma and never smoked status, while never smoked status and good PS were independent prognostic factors in multivariate analysis. Four patients (3.3%) developed interstitial pneumonitis associated with gefitinib. Conclusion: Gefitinib showed favorable antitumor activity in females, never smokers and adenocarcinoma. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -