RT Journal Article
SR Electronic
T1 Diagnostic Utility of Third-Look, Contrast-Enhanced Sonography Followed by Needle Biopsy for MRI, But Not Second-look Ultrasonography-detected Breast Lesions
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 915
OP 921
DO 10.21873/anticanres.13194
VO 39
IS 2
A1 TOMOHIRO MIYAKE
A1 SEUNG JIN KIM
A1 MASAFUMI SHIMODA
A1 NAOFUMI KAGARA
A1 TOMONORI TANEI
A1 YASUTO NAOI
A1 KENZO SHIMAZU
A1 SHINZABURO NOGUCHI
YR 2019
UL http://ar.iiarjournals.org/content/39/2/915.abstract
AB Background/Aim: To clarify the diagnostic utility of third-look, contrast-enhanced ultrasonography (CEUS) for MRI-detected breast lesions undetectable by unenhanced, second-look ultrasonography (MRI+/US− lesions). Patients and Methods: Clinical stage 0–IIA breast cancer patients who underwent CEUS for incidental MRI+/US− lesions (n=27; cohort 1) and patients with breast lesions detected only by MRI, to be examined by CEUS (n=15; cohort 2), were retrospectively analyzed. Results: Of the 42 MRI+/US− lesions, 23 (55%) were detected by CEUS and then examined by needle biopsy. Pathological examination showed that 10 of these 23 lesions were malignant. None of the 19 lesions undetected by CEUS were found to be histologically malignant or developed malignancy with a median follow-up of 18.5 months. The accuracy, sensitivity, and specificity of CEUS plus needle biopsy were 98%, 91%, and 100%, respectively. Conclusion: Third-look CEUS followed by needle biopsy is useful in the initial diagnosis of MRI+/US− lesions.