PT  - JOURNAL ARTICLE
AU  - TOSHIYUKI KAWASHIMA
AU  - MASAKAZU YASHIRO
AU  - HIROAKI KASASHIMA
AU  - YUZO TERAKAWA
AU  - TAKEHIRO UDA
AU  - KOSUKE NAKAJO
AU  - RYOKO UMABA
AU  - YUTA TANOUE
AU  - SAMANTHA TAMRAKAR
AU  - KENJI OHATA
TI  - Oligodendrocytes Up-regulate the Invasive Activity of Glioblastoma Cells <em>via</em> the Angiopoietin-2 Signaling Pathway
AID  - 10.21873/anticanres.13150
DP  - 2019 Feb 01
TA  - Anticancer Research
PG  - 577--584
VI  - 39
IP  - 2
4099  - http://ar.iiarjournals.org/content/39/2/577.short
4100  - http://ar.iiarjournals.org/content/39/2/577.full
SO  - Anticancer Res2019 Feb 01; 39
AB  - Background/Aim: Glioblastoma (GBM) is one of the most lethal solid cancers due to its highly invasive nature. The malignant potential of GBM cells might be partially regulated by surrounding normal cells, such as oligodendrocytes or fibroblasts. The aim of this study was to examine the interaction between stromal cells and GBM cells. Materials and Methods: Two GBM cell lines were used. The effect of stromal cells, oligodendrocytes or fibroblasts, on the invasive ability of GBM cells was examined by wound-healing assay and invasion assay. Results: Oligodendrocytes, in contrast to fibroblasts, significantly increased the migration and invasive ability of GBM cells. Angiopoietin-2 levels were high in the conditioned medium obtained from oligodendrocytes. Angiopoietin-2 significantly increased the motility of GBM, and the motility-stimulating activity of the oligodendrocytes-derived conditioned medium was significantly decreased by anti-angiopoietin-2-neutralizing antibody. Conclusion: Glioma stromal cells, oligodendrocytes, might up-regulate the invasiveness of GBM cells via angiopoietin-2 signaling.