RT Journal Article
SR Electronic
T1 Cyclin D1 Overexpression is Associated with Estrogen Receptor Expression in Caucasian but not African-American Breast Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 273
OP 281
VO 25
IS 1A
A1 ANDREW K. JOE
A1 LORENZO MEMEO
A1 JUDITH MCKOY
A1 MAHESH MANSUKHANI
A1 HUI LIU
A1 ALEXA AVILA-BRONT
A1 JENNY ROMERO
A1 HUILING LI
A1 ANDREA TROXEL
A1 HANINA HIBSHOOSH
YR 2005
UL http://ar.iiarjournals.org/content/25/1A/273.abstract
AB Background: African-American (AA) breast cancer patients consistently show a shortened survival when compared with Caucasian patients. This worse prognosis is most likely due to a combination of socioeconomic factors and differences in tumor biology. Previous studies have demonstrated that cyclin D1 overexpression is strongly associated with estrogen receptor (ER) expression in breast cancer, but these series either included primarily Caucasian patients or did not specify race. Materials and Methods: We analyzed 200 breast cancer cases obtained from AA and Caucasian patients who were matched on age, stage, ER status, and year of diagnosis. We examined expression levels of cyclin D1, p53, p27Kip1 (p27), and p21Cip1 (p21), and correlated their expression with ER status. Results: Cyclin D1, p53, p27, and p21 expression rates were similar in matched cases of AA and Caucasian breast cancer (p values>0.05). However, cyclin D1 overexpression was significantly associated with ER status in only the Caucasian (p=0.0005), and not the AA cases (p=0.07). Conclusion: This finding suggests a novel biological difference, which may contribute to the more aggressive phenotype of AA breast cancer.