RT Journal Article SR Electronic T1 Pathological Complete Remission of Liver Metastases Correlates With Elimination of Tumor-infiltrating Tregs in Gastric Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1571 OP 1577 DO 10.21873/anticanres.14917 VO 41 IS 3 A1 YASUTAKA NAKANISHI A1 SEIICHI HIROTA A1 YUDAI HOJO A1 TATSURO NAKAMURA A1 TSUTOMU KUMAMOTO A1 YASUNORI KURAHASHI A1 YOSHINORI ISHIDA A1 HISASHI SHINOHARA YR 2021 UL http://ar.iiarjournals.org/content/41/3/1571.abstract AB Background/Aim: Tumor-infiltrating Foxp3+ regulatory T-cells (Ti-Tregs) promote tumor progression and contribute to poor prognosis in gastric cancer, but the relationship between Ti-Tregs and response to chemotherapy for liver metastases from gastric cancer (LMGC) is unclear. We estimated the correlation between pathological response to chemotherapy and Ti-Tregs in LMGC. Patients and Methods: Ti-Tregs were analyzed with immunohistochemistry as CD3+ Foxp3+ cells in patients with synchronous LMGC. Results: Of 53 patients with LMGC, 49 received chemotherapy as initial treatment and 10 underwent R0 resection. LMGC disappeared pathologically in 5 resected cases despite radiologically residual disease. Ti-Tregs were found frequently in residual LMGC and primary lesions but rarely in tumor scar tissue. There was no relationship between frequency of CD8+ cells and pathological response. Conclusion: Marked reduction in Ti-Tregs correlates with pathological complete remission of LMGC. Ti-Tregs may be a biomarker to predict the effects of chemotherapy when used in combination with radiological findings.