TY - JOUR T1 - The Expression of PEDF and its Putative Receptors in Hepatocellular Carcinoma and Background Liver Tissue JF - Anticancer Research JO - Anticancer Res SP - 1203 LP - 1212 DO - 10.21873/anticanres.14877 VL - 41 IS - 3 AU - JUN AKIBA AU - TAKAFUMI YOSHIDA AU - EIJI SADASHIMA AU - KAZUYA MURATA AU - TAKANORI MATSUI AU - SHO-ICHI YAMAGISHI AU - HIRONORI KUSANO AU - YUTARO MIHARA AU - SHINJI MIZUOCHI AU - YOSHINAO KINJOU AU - YOSHIKI NAITO AU - TORU HISAKA AU - HISAMUNE SAKAI AU - KOJI OKUDA AU - OSAMU NAKASHIMA AU - HIROHISA YANO Y1 - 2021/03/01 UR - http://ar.iiarjournals.org/content/41/3/1203.abstract N2 - Background/Aim: Hepatocellular carcinoma (HCC) remains one of the biggest medical issues. Pigment epithelial-derived factor (PEDF) is a glycoprotein that belongs to the superfamily of serine protease inhibitors. PEDF interacts with its two receptors, adipose triglyceride lipase (ATGL) and laminin receptor (LR). Materials and Methods: We conducted immunohistochemical staining for PEDF, LR and ATGL in 151 resected HCCs and their background liver tissues. Results: High expression of LR in HCC was associated with high histological grade and portal vein invasion, while high expression of PEDF in HCC was associated with absence of portal vein invasion. High LR expression in background liver was statistically associated with low serum albumin levels and was an independent prognostic factor of worse outcomes. No cases with more than 5% fatty degeneration in the background liver tissue showed high PEDF expression. Conclusion: PEDF/LR/ATGL could be potential biomarkers in HCC and various chronic hepatic disorders. ER -