RT Journal Article
SR Electronic
T1 Annexin A10 Expression Is Associated With Poor Prognosis in Small Bowel Adenocarcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1349
OP 1355
DO 10.21873/anticanres.14892
VO 41
IS 3
A1 AKIRA ISHIKAWA
A1 KAZUYA KURAOKA
A1 JUNICHI ZAITSU
A1 AKIHISA SAITO
A1 TOSHIO KUWAI
A1 YOSUKE SHIMIZU
A1 TAKESHI SUDO
A1 HIROTAKA TASHIRO
A1 KIYOMI TANIYAMA
A1 WATARU YASUI
YR 2021
UL http://ar.iiarjournals.org/content/41/3/1349.abstract
AB Background/Aim: Small bowel adenocarcinoma (SBA) is a relatively rare malignant epithelial neoplasm. Thus, little is known about prognostic biomarkers of SBA. Annexin A10 (ANXA10) is a member of the annexin family. The significance of ANXA10 expression in SBA is unclear. This is the first study to examine the expression of ANXA10 in SBA. Materials and Methods: We immunohistochemically evaluated ANXA10 expression of SBA and studied the relationship between ANXA10 expression and clinicopathological factors. Results: ANXA10 expression was detected in 17 (56.7%) of 30 SBA cases and was significantly associated with poor overall survival. Univariate predictors for poor prognosis were tumour size (p=0.017) and ANXA10 expression (p=0.026). In multivariate analysis, ANXA10 expression (p=0.038) and tumour size (p=0.024) were found to be independent predictors of poor prognosis. Conclusion: ANXA10 could be a new prognostic biomarker for SBA.