TY - JOUR T1 - Annexin A10 Expression Is Associated With Poor Prognosis in Small Bowel Adenocarcinoma JF - Anticancer Research JO - Anticancer Res SP - 1349 LP - 1355 DO - 10.21873/anticanres.14892 VL - 41 IS - 3 AU - AKIRA ISHIKAWA AU - KAZUYA KURAOKA AU - JUNICHI ZAITSU AU - AKIHISA SAITO AU - TOSHIO KUWAI AU - YOSUKE SHIMIZU AU - TAKESHI SUDO AU - HIROTAKA TASHIRO AU - KIYOMI TANIYAMA AU - WATARU YASUI Y1 - 2021/03/01 UR - http://ar.iiarjournals.org/content/41/3/1349.abstract N2 - Background/Aim: Small bowel adenocarcinoma (SBA) is a relatively rare malignant epithelial neoplasm. Thus, little is known about prognostic biomarkers of SBA. Annexin A10 (ANXA10) is a member of the annexin family. The significance of ANXA10 expression in SBA is unclear. This is the first study to examine the expression of ANXA10 in SBA. Materials and Methods: We immunohistochemically evaluated ANXA10 expression of SBA and studied the relationship between ANXA10 expression and clinicopathological factors. Results: ANXA10 expression was detected in 17 (56.7%) of 30 SBA cases and was significantly associated with poor overall survival. Univariate predictors for poor prognosis were tumour size (p=0.017) and ANXA10 expression (p=0.026). In multivariate analysis, ANXA10 expression (p=0.038) and tumour size (p=0.024) were found to be independent predictors of poor prognosis. Conclusion: ANXA10 could be a new prognostic biomarker for SBA. ER -