RT Journal Article
SR Electronic
T1 Clinical Trial of a Cancer Vaccine Targeting VEGF and KIF20A in Advanced Biliary Tract Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1485
OP 1496
DO 10.21873/anticanres.14907
VO 41
IS 3
A1 MURAHASHI, MUTSUNORI
A1 TSURUTA, TOSHIHISA
A1 YAMADA, KAZUNARI
A1 HIJIKATA, YASUKI
A1 OGATA, HISANOBU
A1 KISHIMOTO, JUNJI
A1 YOSHIMURA, SACHIKO
A1 HIKICHI, TETSURO
A1 NAKANISHI, YOICHI
A1 TANI, KENZABURO
YR 2021
UL http://ar.iiarjournals.org/content/41/3/1485.abstract
AB Background: As the prognosis of biliary tract cancer (BTC) is extremely poor and treatment options are limited, new treatment modalities are urgently needed. We designed a phase II clinical trial to investigate the immune responses and clinical benefits of OCV-C01, an HLA-A*24:02–restricted three-peptide cancer vaccine targeting VEGFR1, VEGFR2, and KIF20A. Patients and Methods: Participants were patients with advanced BTC who had unresectable tumours and were refractory to standard chemotherapy. OCV-C01 was injected weekly until the discontinuance criteria were met. Results: Six participants, including four patients positive for HLA-A*24:02, were enrolled in this study for assessment of efficacy. Four out of six patients exhibited vaccine-specific T-cell responses to one or more of three antigens. Log–rank tests revealed that vaccine-specific T cell responses contributed significantly to overall survival. Conclusion: The cancer vaccine had positive effects on survival, indicating that this approach warrants further clinical studies.