RT Journal Article
SR Electronic
T1 Calorie Restriction Suppresses the Progression of Radiation-Induced Intestinal Tumours in C3B6F1 <em>Apc</em><sup><em>Min</em>/+</sup> Mice
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1365
OP 1375
DO 10.21873/anticanres.14894
VO 41
IS 3
A1 TAKAMITSU MORIOKA
A1 SHUNSUKE YAMAZAKI
A1 HIROMI YANAGIHARA
A1 MASAAKI SUNAOSHI
A1 MUTSUMI KAMINISHI
A1 SHIZUKO KAKINUMA
YR 2021
UL http://ar.iiarjournals.org/content/41/3/1365.abstract
AB Background/Aim: Progress in cancer treatment and diagnosis has made second cancer after medical radiation exposure a particular concern among childhood cancer survivors. Calorie restriction (CR) is a broadly effective cancer prevention strategy, although its effects on radiation-induced intestinal tumours are unclear. Here we examined the cancer-preventative efficacy of a CR diet at different starting ages on radiation induction of intestinal tumours in mice. Materials and Methods: Male C3B6F1 ApcMin/+ mice were irradiated with 0 or 2 Gy of X-rays at 2 weeks of age. After an interval of 2, 8 or 18 weeks, mice were fed with a non-CR (95 kcal/week/mouse) or CR (65 kcal/week/mouse) diet. Intestinal tumours were evaluated for number, size distribution and malignancy. Results: CR suppressed the size and progression of both spontaneous and radiation-induced intestinal tumours depending on age at starting of CR. CR diets were effective even administered to adult mice. Conclusion: CR was effective for suppression of tumour progression, which was accelerated by radiation exposure. Use of CR might be a useful cancer-prevention strategy for radiation-induced tumours of the intestinal tract.