PT - JOURNAL ARTICLE AU - ACHIM M. FRANZEN AU - JOCHEN P. WINDFUHR TI - Tonsillectomy as a Prevention Strategy in the Light of Increasing Incidence of Oropharyngeal Cancer – a Research of Current Literature AID - 10.21873/anticanres.14872 DP - 2021 Mar 01 TA - Anticancer Research PG - 1157--1161 VI - 41 IP - 3 4099 - http://ar.iiarjournals.org/content/41/3/1157.short 4100 - http://ar.iiarjournals.org/content/41/3/1157.full SO - Anticancer Res2021 Mar 01; 41 AB - Background/Aim: While in many Western countries the number of tonsillectomies decreases significantly, there is an increasing incidence of oropharyngeal carcinomas. For, obviously, removal of the tonsils will reduce individual risk for tonsil cancer, the question of tonsillectomy as a prevention strategy is suggested. This study focused on this question by carrying out a literature research. Materials and Methods: A literature research was performed (www.pubmed.gov; Search words: tonsillectomy, oropharyngeal cancer, tonsil cancer, prevention) without applying additional filters. Results: Out of the 16 identified studies, three population-based studies were evaluated. Individual incidence of tonsil cancer is significantly lower after removal of tonsils; however, risk elimination by tonsillectomy has not been proven. One of the studies revealed increasing numbers of base of the tongue cancer after previous tonsillectomy. Conclusion: The increase in oropharynx carcinomas can currently be attributed not to the decreasing tonsillectomy rates, but to the increase in HPV infections. A previous tonsillectomy reduces the individual risk of developing tonsil carcer. Tonsillectomy as prevention for oropharyngeal cancer cannot be recommended and may even be a disadvantage concerning base of the tongue cancers.