RT Journal Article
SR Electronic
T1 Nondysplastic Crypts in Fission in Nonpolypoid Adenomas and in the Adjacent Mucosa Support Field Cancerization in the Colon
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1515
OP 1521
DO 10.21873/anticanres.14910
VO 41
IS 3
A1 CARLOS A. RUBIO
A1 PETER T. SCHMIDT
YR 2021
UL http://ar.iiarjournals.org/content/41/3/1515.abstract
AB Background/Aim: We recently noticed in nonpolypoid adenomas (NPA) and the adjacent normal mucosa, nondysplastic crypts in symmetric and asymmetric fission (NDCSAF). Patients and Methods: All NDCSAF found in 80 small NPA and in the adjacent mucosa were registered. Results: A total of 178 NDCSAF (mean, 2.2) were found: 12 (6.7%) interspersed between adenomatous glands, 36 (20.2%) partially replaced by dysplastic epithelium, and 130 (73%) underneath the adenomatous tissue. Of the 61 cases with normal mucosa adjacent to NPA, 40 (65.6%) disclosed NDCSAF, and the remaining 21 (34.4%) normal crypts, exclusively. Conclusion: The accruing of NDCSAF within NPA and surrounding mucosa, are outstanding findings. Given that colonic crypts may undergo only one fission every 30-40 years, the accruing of NDCSAF in and about small NPA reveals mucosal hubs with pathological aberrations of cryptogenesis, probably conveyed by somatic mutations. The findings support the existence of field cancerization in the colonic mucosa.