TY - JOUR T1 - Nondysplastic Crypts in Fission in Nonpolypoid Adenomas and in the Adjacent Mucosa Support Field Cancerization in the Colon JF - Anticancer Research JO - Anticancer Res SP - 1515 LP - 1521 DO - 10.21873/anticanres.14910 VL - 41 IS - 3 AU - CARLOS A. RUBIO AU - PETER T. SCHMIDT Y1 - 2021/03/01 UR - http://ar.iiarjournals.org/content/41/3/1515.abstract N2 - Background/Aim: We recently noticed in nonpolypoid adenomas (NPA) and the adjacent normal mucosa, nondysplastic crypts in symmetric and asymmetric fission (NDCSAF). Patients and Methods: All NDCSAF found in 80 small NPA and in the adjacent mucosa were registered. Results: A total of 178 NDCSAF (mean, 2.2) were found: 12 (6.7%) interspersed between adenomatous glands, 36 (20.2%) partially replaced by dysplastic epithelium, and 130 (73%) underneath the adenomatous tissue. Of the 61 cases with normal mucosa adjacent to NPA, 40 (65.6%) disclosed NDCSAF, and the remaining 21 (34.4%) normal crypts, exclusively. Conclusion: The accruing of NDCSAF within NPA and surrounding mucosa, are outstanding findings. Given that colonic crypts may undergo only one fission every 30-40 years, the accruing of NDCSAF in and about small NPA reveals mucosal hubs with pathological aberrations of cryptogenesis, probably conveyed by somatic mutations. The findings support the existence of field cancerization in the colonic mucosa. ER -