RT Journal Article
SR Electronic
T1 Expression Patterns of ERα, ERβ, AR, SIRT1, SIRT2, and SIRT3 in Prostate Cancer Tissue and Normal Prostate Tissue
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1377
OP 1386
DO 10.21873/anticanres.14895
VO 41
IS 3
A1 JAE HWI CHOI
A1 SEE MIN CHOI
A1 SIN WOO LEE
A1 SEONG UK JEH
A1 JAE SEOG HYUN
A1 MIN HO LEE
A1 CHUNWOO LEE
A1 SUNG CHUL KAM
A1 DONG CHUL KIM
A1 JONG SIL LEE
A1 JEONG SEOK HWA
YR 2021
UL http://ar.iiarjournals.org/content/41/3/1377.abstract
AB Background/Aim: The purpose of this study was to examine the expression of estrogen receptor α (ERα) and β (ERβ), androgen receptor (AR), SIRT1, SIRT2 and SIRT3 in prostate cancer (PCa). Materials and Methods: From October 2010 to January 2015, 70 patients who had undergone radical prostatectomy following a PCa diagnosis were enrolled in our study. Normal prostate tissue (NPT) and prostate cancer tissues (PCAT) were separated, and the expression of each receptor in each tissue was analyzed with immunochemical staining. Univariate and multivariate analyses were performed to identify factors affecting the development of PCa. Results: ERβ and AR were highly expressed in PCAT compared with NPT (p<0.05). SIRT2 was highly expressed in NPT and PCAT (p<0.05). Univariate and multivariate analyses showed that AR and SIRT2 affect PCa development. Conclusion: AR is a risk factor for PC, and SIRT2 is associated with a lower incidence of PCa.