PT - JOURNAL ARTICLE AU - JAE HWI CHOI AU - SEE MIN CHOI AU - SIN WOO LEE AU - SEONG UK JEH AU - JAE SEOG HYUN AU - MIN HO LEE AU - CHUNWOO LEE AU - SUNG CHUL KAM AU - DONG CHUL KIM AU - JONG SIL LEE AU - JEONG SEOK HWA TI - Expression Patterns of ERα, ERβ, AR, SIRT1, SIRT2, and SIRT3 in Prostate Cancer Tissue and Normal Prostate Tissue AID - 10.21873/anticanres.14895 DP - 2021 Mar 01 TA - Anticancer Research PG - 1377--1386 VI - 41 IP - 3 4099 - http://ar.iiarjournals.org/content/41/3/1377.short 4100 - http://ar.iiarjournals.org/content/41/3/1377.full SO - Anticancer Res2021 Mar 01; 41 AB - Background/Aim: The purpose of this study was to examine the expression of estrogen receptor α (ERα) and β (ERβ), androgen receptor (AR), SIRT1, SIRT2 and SIRT3 in prostate cancer (PCa). Materials and Methods: From October 2010 to January 2015, 70 patients who had undergone radical prostatectomy following a PCa diagnosis were enrolled in our study. Normal prostate tissue (NPT) and prostate cancer tissues (PCAT) were separated, and the expression of each receptor in each tissue was analyzed with immunochemical staining. Univariate and multivariate analyses were performed to identify factors affecting the development of PCa. Results: ERβ and AR were highly expressed in PCAT compared with NPT (p<0.05). SIRT2 was highly expressed in NPT and PCAT (p<0.05). Univariate and multivariate analyses showed that AR and SIRT2 affect PCa development. Conclusion: AR is a risk factor for PC, and SIRT2 is associated with a lower incidence of PCa.