RT Journal Article
SR Electronic
T1 Acute Kidney Injury Following Hyperthermic Intraperitoneal Chemotherapy With Cisplatin
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1641
OP 1646
DO 10.21873/anticanres.14926
VO 41
IS 3
A1 KERRY L. CHEN
A1 RAPHAEL SHAMAVONIAN
A1 JOSH B. KARPES
A1 NAYEF A. ALZAHRANI
A1 DAVID L. MORRIS
YR 2021
UL http://ar.iiarjournals.org/content/41/3/1641.abstract
AB Background/Aim: Cisplatin increases the risk of acute kidney injury (AKI) during systemic chemotherapy. However, little is known about its risk of inducing AKI when used during intraperitoneal chemotherapy. This study aimed to determine the incidence of AKI in patients undergoing cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) with cisplatin. Patients and Methods: A retrospective analysis of patients who received cisplatin-based HIPEC from November 2008 to March 2018 was undertaken to determine the incidence of AKI. Results: A total of 111 patients were identified. The incidence of AKI was 15.3% (17/111). Univariate analysis showed increased peritoneal cancer index (PCI), low intraoperative and post-operative urine output were significantly associated with the development of AKI. Multivariate analyses did not identify any significant predictors factors for AKI. Conclusion: Cisplatin-based HIPEC is associated with AKI. At our centre, the incidence of AKI was 15.3%. Risk factors that may influence its development include high PCI and low perioperative diuresis.