TY - JOUR T1 - Blood Cell Count Biomarkers Predicting Efficacy of Pembrolizumab as Second-line Therapy for Advanced Urothelial Carcinoma JF - Anticancer Research JO - Anticancer Res SP - 1599 LP - 1606 DO - 10.21873/anticanres.14921 VL - 41 IS - 3 AU - YOSHIFUMI KADONO AU - SHOHEI KAWAGUCHI AU - TAKAHIRO NOHARA AU - KAZUYOSHI SHIGEHARA AU - KOUJI IZUMI AU - TAIKI KAMIJIMA AU - CHIKASHI SETO AU - AKINOBU TAKANO AU - SATOSHI YOTSUYANAGI AU - RYUNOSUKE NAKAGAWA AU - TOHRU MIYAGI AU - SHUHEI AOYAMA AU - HIDEKI ASAHI AU - RIE FUKUDA AU - ATSUSHI MIZOKAMI Y1 - 2021/03/01 UR - http://ar.iiarjournals.org/content/41/3/1599.abstract N2 - Background/Aim: To investigate the blood markers for predicting pembrolizumab efficacy in advanced urothelial carcinoma (UC). Patients and Methods: This study included 91 advanced UC patients. The relationship between prognosis and markers from peripheral blood cell counts, including the neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), monocyte–lymphocyte ratio (MLR), and systemic inflammation response index (SIRI=monocytes × neutrophils/lymphocytes), was evaluated. Results: Multivariate analysis indicated that pretreatment NLR and the 1-month-change NLR were both significantly associated with overall survival (OS) after pembrolizumab initiation. When the patients were divided into four groups according to calculated cutoffs using Cox proportional hazard model, the pretreatment NLR <2.9 and 1-month change NLR <+43% groups had a significantly better OS than the pretreatment NLR ≥2.9 and 1-month-change NLR ≥+43% groups. Conclusion: NLR, MLR, PLR and SIRI before pembrolizumab and 1-month-change NLR in advanced UC correlated with OS after pembrolizumab treatment. ER -