@article {KADONO1599, author = {YOSHIFUMI KADONO and SHOHEI KAWAGUCHI and TAKAHIRO NOHARA and KAZUYOSHI SHIGEHARA and KOUJI IZUMI and TAIKI KAMIJIMA and CHIKASHI SETO and AKINOBU TAKANO and SATOSHI YOTSUYANAGI and RYUNOSUKE NAKAGAWA and TOHRU MIYAGI and SHUHEI AOYAMA and HIDEKI ASAHI and RIE FUKUDA and ATSUSHI MIZOKAMI}, title = {Blood Cell Count Biomarkers Predicting Efficacy of Pembrolizumab as Second-line Therapy for Advanced Urothelial Carcinoma}, volume = {41}, number = {3}, pages = {1599--1606}, year = {2021}, doi = {10.21873/anticanres.14921}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: To investigate the blood markers for predicting pembrolizumab efficacy in advanced urothelial carcinoma (UC). Patients and Methods: This study included 91 advanced UC patients. The relationship between prognosis and markers from peripheral blood cell counts, including the neutrophil{\textendash}lymphocyte ratio (NLR), platelet{\textendash}lymphocyte ratio (PLR), monocyte{\textendash}lymphocyte ratio (MLR), and systemic inflammation response index (SIRI=monocytes {\texttimes} neutrophils/lymphocytes), was evaluated. Results: Multivariate analysis indicated that pretreatment NLR and the 1-month-change NLR were both significantly associated with overall survival (OS) after pembrolizumab initiation. When the patients were divided into four groups according to calculated cutoffs using Cox proportional hazard model, the pretreatment NLR \<2.9 and 1-month change NLR \<+43\% groups had a significantly better OS than the pretreatment NLR >=2.9 and 1-month-change NLR >=+43\% groups. Conclusion: NLR, MLR, PLR and SIRI before pembrolizumab and 1-month-change NLR in advanced UC correlated with OS after pembrolizumab treatment.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/41/3/1599}, eprint = {https://ar.iiarjournals.org/content/41/3/1599.full.pdf}, journal = {Anticancer Research} }