@article {CHMARA4259, author = {MAGDALENA CHMARA and AGNIESZKA WOZNIAK and KAROLINA OCHMAN and GRAZYNA KOBIERSKA and RAFAL DZIADZIUSZKO and KATARZYNA SOSINSKA-MIELCAREK and EWA JASSEM and JAN SKOKOWSKI and JACEK JASSEM and JANUSZ LIMON}, title = {Loss of Heterozygosity at Chromosomes 3p and 17p in Primary Non-small Cell Lung Cancer}, volume = {24}, number = {6}, pages = {4259--4264}, year = {2004}, publisher = {International Institute of Anticancer Research}, abstract = {Background: Loss of heterozygosity (LOH) of selected regions at chromosomes 3p and 17p in non-small cell lung cancer (NSCLC) and the association of these abnormalities with major clinical parameters and prognosis were studied. Materials and Methods: The study group included 92 consecutive primary NSCLC tumours and four microsatellite markers from chromosome 3p and three markers from 17p were analyzed. Results: LOH of at least one locus was found in 83\% of all analyzed tumours. Most frequently deletion (58\%) was found at locus D3S1481 (3p14.2). Sequence deletions of D17S520 (17p12) and TP53 (17p13.1) occurred in 52\% of tumours. LOH occurrence at 3p and 17p was more frequent in squamous cell carcinomas compared to adenocarcinomas (89\% vs. 75\%), but this difference was not significant. Conclusion: No significant association was found between LOH on any analyzed loci and tumour stage (TNM) and grade (G). There was no correlation between LOH and survival. Copyright{\textcopyright} 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/24/6/4259}, eprint = {https://ar.iiarjournals.org/content/24/6/4259.full.pdf}, journal = {Anticancer Research} }