PT - JOURNAL ARTICLE AU - EEVA RAHKO AU - ARJA JUKKOLA AU - JUKKA MELKKO AU - PÄÄKKÖ PAAVO AU - RISTO BLOIGU AU - ANNE TALVENSAARI-MATTILA AU - TAINA TURPEENNIEMI-HUJANEN TI - Matrix Metalloproteinase-9 (MMP-9) Immunoreactive Protein has Modest Prognostic Value in Locally Advanced Breast Carcinoma Patients Treated with an Adjuvant Antiestrogen Therapy DP - 2004 Nov 01 TA - Anticancer Research PG - 4247--4254 VI - 24 IP - 6 4099 - http://ar.iiarjournals.org/content/24/6/4247.short 4100 - http://ar.iiarjournals.org/content/24/6/4247.full SO - Anticancer Res2004 Nov 01; 24 AB - Background: Matrix metalloproteinases (MMPs) are involved with tumour invasion and metastasis. Controversial data exists concerning the prognostic value of MMP-9 in breast carcinoma. We examined, here, whether the MMP-9 immunoreactive protein would correlate with the prognosis in breast carcinoma treated with hormonal adjuvant therapy. Materials and Methods: The MMP-9 status was determined immunohistochemically from primary tumour specimens in 168 postmenopausal breast cancer patients with a locally advanced (N+) disease treated with antiestrogen for three years after the primary therapy. Results: A positive immunostaining for MMP-9 was found in 61.3% of 168 primary tumours without any significant correlation to clinical stage, histology or hormone receptor status. MMP-9 immunoreactivity did not correlate with the survival when the entire study population was included in the analysis. There was, however, a compromised disease-free survival in a subgroup of patients presenting with an estrogen receptor-negative and MMP-9-positive tumour. The 5-year disease-free survival was only 37% in those patients, when it was 63% in the patients with a tumour negative for both estrogen receptor and MMP-9. Conclusion: We suggest that the prognostic value of MMP-9 immunoreactivity in the primary tumour is not generally strong in breast carcinoma, but it might correlate with the clinical benefit of an antiestrogen therapy, since MMP-9 positivity seemed to correlate with early recurrence in patients with an estrogen receptor-negative primary tumour. Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved