@article {HELLBERG611, author = {DAN HELLBERG and ANNIKA K. LINDSTR{\"O}M and ULF STENDAHL}, title = {Correlation Between Serum Estradiol/Progesterone Ratio and Survival Length in Invasive Squamous Cell Cervical Cancer}, volume = {25}, number = {1B}, pages = {611--616}, year = {2005}, publisher = {International Institute of Anticancer Research}, abstract = {Background: There is epidemiological and laboratory evidence for an association between invasive squamous cell cervical cancer and female sex steroid hormones, such as oral contraceptives. Materials and Methods: Premenopausal (n=72) and postmenopausal (n=118) women with invasive squamous epithelial cervical cancer were included in this study. Serum estradiol and progesterone and DNA S-phase fraction as a measure of proliferative activity were analysed, in 51 pre-, and 77 postmenopausal women, among whom 13 and 43, respectively, died from disease. Results: There was a significant positive correlation between a low serum estradiol/progesterone ratio and short survival in those premenopausal women who eventually died from cancer (p=0.02). Clinical stage was similar when the estradiol/progesterone ratio was dichotomized. There was no association between estradiol/progesterone ratio and survival-months in postmenopausal women. In both pre- and postmenopausal women deceased from cervical cancer, a S-phase fraction at or above 12\% was correlated with reduced survival-months (p=0.03). Conclusion: These results, if confirmed, contribute to bridging the gap between previous epidemiological and laboratory findings of an association between female sex steroid hormones and squamous cell cervical cancer. Copyright{\textcopyright} 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/25/1B/611}, eprint = {https://ar.iiarjournals.org/content/25/1B/611.full.pdf}, journal = {Anticancer Research} }