PT  - JOURNAL ARTICLE
AU  - MARCO BONONI
AU  - ADRIANO TOCCHI
AU  - VINCENZO CANGEMI
AU  - ALDO VECCHIONE
AU  - MARIA ROSARIA GIOVAGNOLI
AU  - ALESSANDRO DE CESARE
AU  - ENRICO FIORI
AU  - PATRIZIA VOLPINO
AU  - STEFANIA BROZZETTI
AU  - MASSIMO MEUCCI
AU  - STEFANO SCOZZAFAVA
AU  - ANTONINO CAVALLARO
TI  - Lymph Node Dissection in Papillary or Follicular Thyroid Carcinoma
DP  - 2004 Jul 01
TA  - Anticancer Research
PG  - 2439--2442
VI  - 24
IP  - 4
4099  - http://ar.iiarjournals.org/content/24/4/2439.short
4100  - http://ar.iiarjournals.org/content/24/4/2439.full
SO  - Anticancer Res2004 Jul 01; 24
AB  - Background: Prospective randomized studies aimed at evaluating the different therapeutic protocols for the treatment of papillary or follicular carcinoma are lacking at the moment. Although total thyroidectomy is widely accepted, indication to locoregional lymphadenectomy is strongly debated. Materials and Methods: Fifty-four patients with papillary or follicular thyroid carcinoma (45 papillary and 9 follicular) underwent functional evaluation of the gland before intervention, FNAB included. Surgical management was carried out as follows: 41 total thyroidectomy, 6 lobectomy with further totalization in 5, 6 total thyroidectomy plus central compartment lymphadenectomy and 1 left laterocervical lymphadenectomy (papillary carcinoma, treated elsewhere through total thyroidectomy plus central and right laterocervical lymphadenectomy). All operated patients were submitted to whole body scintigraphy and treated thereafter by radiometabolic therapy and chronic hormone suppressive therapy. Results: Fifty-one patients are currently alive, 3 died from non-related causes; surgical complications included 1 permanent impairment of inferior laryngeal nerve function and 1 case of hypoparathyroidism. The follow-up was from 1 to 139 months. Discussion: The optimal treatment of lymph node metastases, especially for papillary carcinomas, has not yet been defined. Two trends are evident concerning lymphadenectomy: the first one suggests routine lymphadenectomy, the second supports lymphadenectomy by necessity. In follicular carcinoma lymphadenectomy is recommended only in the presence of clinical evidence of lymph node involvement. Occult differentiated carcinoma does not require any further treatment of lymph nodes. Conclusion: Considering the high efficacy of radiometabolic treatment after total thyroidectomy combined with chronic TSH inhibition through L-tyrosine administration, lymphadenectomy is suggested only by necessity. Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved