RT Journal Article
SR Electronic
T1 Absence of BRAF Gene Mutations Differentiates Spitz Nevi from Malignant Melanoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2415
OP 2418
VO 24
IS 4
A1 MIHIC-PROBST, DANIELA
A1 PERREN, AUREL
A1 SCHMID, SONJA
A1 SAREMASLANI, PARVIN
A1 KOMMINOTH, PAUL
A1 HEITZ, PHILIPP U.
YR 2004
UL http://ar.iiarjournals.org/content/24/4/2415.abstract
AB Background: Distinction of Spitz nevus from malignant melanoma is sometimes difficult on the basis of conventional histology. A high rate of BRAF gene mutations in malignant melanomas (66%) and nevi (82%) has recently been reported. Materials and Methods: We screened a series of 20 Spitz nevi for BRAF mutations in exons 11 and 15 by denaturing gradient gel electrophoresis (DGGE). Results: BRAF mutations could not be identified in Spitz nevi. Conclusion: Our results show that mutations within the BRAF gene are useful markers for the differential diagnosis between Spitz nevus and malignant melanoma. Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved