RT Journal Article
SR Electronic
T1 Survival and Prognostic Nomogram for Primary Gastrointestinal Melanoma (PGIM): A Population-based Study
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 967
OP 974
DO 10.21873/anticanres.14850
VO 41
IS 2
A1 BADAKHSHI, HARUN
A1 WANG, ZI-MING
A1 LI, REN-JIE
A1 ISMAIL, MAHMOUD
A1 KAUL, DAVID
YR 2021
UL http://ar.iiarjournals.org/content/41/2/967.abstract
AB Background/Aim: Primary gastrointestinal mucosal melanoma (PGIM) is an aggressive and rare disease, commonly with poor prognosis. We aimed to determine the clinical risk and prognosis of this rare entity. Patients and Methods: Patients (n=962) with PGIM documented in the Surveillance, Epidemiology, and End Results database between 1975-2016 were included. Prognostic factors on overall survival (OS) and cancer-specific survival (CSS) were identified. A nomogram was constructed to predict the OS of PGIM patients. Results: Primary site, summary stage, and therapeutic method were all independent predictors of OS and CSS, and age was the only factor significantly associated with OS. Independent prognostic factors of OS were selected to develop a predictive nomogram. The Harrell’s C-index of the nomogram was 0.712, the area under the curve (AUC) was 0.746, 0.758, 0.810 for the 1-, 3-, and 5-year OS, respectively, and calibration plots were in good agreement. Conclusion: Several prognostic factors of PGIM were demonstrated and a practical nomogram model was created in this study.