PT  - JOURNAL ARTICLE
AU  - HARUN BADAKHSHI
AU  - ZI-MING WANG
AU  - REN-JIE LI
AU  - MAHMOUD ISMAIL
AU  - DAVID KAUL
TI  - Survival and Prognostic Nomogram for Primary Gastrointestinal Melanoma (PGIM): A Population-based Study
AID  - 10.21873/anticanres.14850
DP  - 2021 Feb 01
TA  - Anticancer Research
PG  - 967--974
VI  - 41
IP  - 2
4099  - http://ar.iiarjournals.org/content/41/2/967.short
4100  - http://ar.iiarjournals.org/content/41/2/967.full
SO  - Anticancer Res2021 Feb 01; 41
AB  - Background/Aim: Primary gastrointestinal mucosal melanoma (PGIM) is an aggressive and rare disease, commonly with poor prognosis. We aimed to determine the clinical risk and prognosis of this rare entity. Patients and Methods: Patients (n=962) with PGIM documented in the Surveillance, Epidemiology, and End Results database between 1975-2016 were included. Prognostic factors on overall survival (OS) and cancer-specific survival (CSS) were identified. A nomogram was constructed to predict the OS of PGIM patients. Results: Primary site, summary stage, and therapeutic method were all independent predictors of OS and CSS, and age was the only factor significantly associated with OS. Independent prognostic factors of OS were selected to develop a predictive nomogram. The Harrell’s C-index of the nomogram was 0.712, the area under the curve (AUC) was 0.746, 0.758, 0.810 for the 1-, 3-, and 5-year OS, respectively, and calibration plots were in good agreement. Conclusion: Several prognostic factors of PGIM were demonstrated and a practical nomogram model was created in this study.