TY - JOUR T1 - BP180 Is a Prognostic Factor in Head and Neck Squamous Cell Carcinoma JF - Anticancer Research JO - Anticancer Res SP - 1089 LP - 1099 DO - 10.21873/anticanres.14867 VL - 41 IS - 2 AU - XUE MENG AU - FUMIHIKO MATSUMOTO AU - TAISUKE MORI AU - NAMI MIURA AU - YOSHINORI INO AU - KAORU ONIDANI AU - KENYA KOBAYASHI AU - YUSUKE MATSUZAKI AU - SEIICHI YOSHIMOTO AU - KATSUHISA IKEDA AU - KAZUFUMI HONDA Y1 - 2021/02/01 UR - http://ar.iiarjournals.org/content/41/2/1089.abstract N2 - Background/Aim: Prognosis plays a vital role in head and neck squamous cell carcinoma (HNSCC) patient management and decision-making. This study aimed to identify the role of BP180 as a prognostic factor in HNSCC. Patients and Methods: Protein expression of bullous pemphigoid antigen II (BP180) was verified by immunohistochemistry (IHC) in a tissue microarray study of 202 cases. Results: IHC analysis revealed that protein expression of BP180 among HNSCC patients differed significantly in the presence and absence of neural invasion, and according to T status in laryngeal and pharyngeal cancer subgroups. Overall survival and multivariate analysis showed that positive BP180-IHC and advanced clinical stage were significant independent positive predictors of mortality in HNSCC patients. In addition, in the oral cancer subgroup, independent positive predictors were positive BP180-IHC, advanced N status and neural invasion. In laryngeal and pharyngeal cancer subgroups, predictors were positive BP180-IHC and advanced clinical stage. Conclusion: BP180 is a prognostic factor in head and neck squamous cell carcinoma. ER -