PT  - JOURNAL ARTICLE
AU  - BENJAMIN NISMAN
AU  - TANIR M. ALLWEIS
AU  - EINAT CARMON
AU  - LUNA KADOURI
AU  - BELLA MALY
AU  - OFRA MAIMON
AU  - AMICHAY MEIROVITZ
AU  - TAMAR PERETZ
TI  - Elevated Free Triiodothyronine Is Associated With Increased Proliferative Activity in Triple-negative Breast Cancer
AID  - 10.21873/anticanres.14848
DP  - 2021 Feb 01
TA  - Anticancer Research
PG  - 949--954
VI  - 41
IP  - 2
4099  - http://ar.iiarjournals.org/content/41/2/949.short
4100  - http://ar.iiarjournals.org/content/41/2/949.full
SO  - Anticancer Res2021 Feb 01; 41
AB  - Background/Aim: Thyroid hormones (THs) stimulate breast cancer (BC) cell proliferation. We hypothesized that these hormones and the proliferative marker thymidine kinase 1 (TK1) represent the initial and final steps of the proliferative pathway, respectively. Patients and Methods: We measured the serum levels of thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4), along with serum TK1 activity, in 144 newly diagnosed BC patients, and examined the associations between THs and proliferation in different BC receptor profiles. Results: TK1 activity did not correlate with TSH (r=0.06, p=0.473) or FT4 levels (r=0.04, p=0.665), but did correlate with FT3 levels (r=0.28, p=0.001). Elevated FT3 (>6.0 pmol/l) predicted increased TK1 activity (>140 Du/l) after adjusting for age (odds ratio 4.1, p=0.014). We also found a significant association of the combined elevation of FT3 and TK1, assumed as a surrogate marker of accomplished proliferative signal, with triple-negative (TN) profile (p=0.003). The rates of combined FT3 and TK1 elevation in TN and ER-positive profiles were 20.0% and 1.8%, respectively (p=0.005). Conclusion: FT3 may be involved in proliferative signaling, as measured by TK1 activity, predominately in TN breast cancer.