RT Journal Article
SR Electronic
T1 Determination of Deformable Image Registration Algorithms for Accumulating Dose in Carbon-ion Radiotherapy for Pancreatic Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 835
OP 843
DO 10.21873/anticanres.14836
VO 41
IS 2
A1 YANG LI
A1 YOSHIKI KUBOTA
A1 MASAHIKO OKAMOTO
A1 SHINTARO SHIBA
A1 SHOHEI OKAZAKI
A1 TOSHIAKI MATSUI
A1 SHUNICHIRO KOMATSU
A1 TATSUYA OHNO
YR 2021
UL http://ar.iiarjournals.org/content/41/2/835.abstract
AB Background/Aim: This study aimed to determine appropriate deformable image registration (DIR) algorithms for pancreatic cancer patients undergoing carbon ion radiotherapy (CIRT). Patients and Methods: The performance of three types of DIR algorithms, including intensity-based DIR (iDIR), contour-based DIR (cDIR), and hybrid DIR (hDIR) were evaluated using seventy-one CT images from eight pancreatic cancer patients. Both the geometry of the CTV and subsequent dose warping discrepancies were evaluated using the dice similarity coefficient (DSC) and the difference in V95. Results: cDIR and hDIR had superior performance than iDIR in both DSC and V95 (p<0.0001). iDIR caused accumulated dose to be underestimated by 5% in the median CTV V95 compared to the other methods. Conclusion: hDIR and cDIR can be utilized to assess the accumulated dose in CIRT for pancreatic cancer. iDIR can be considered when the obtained DSC is greater than 0.89.