TY - JOUR T1 - Prognostic Influence of Cytoplasmic/Nuclear Hepatoma-derived Growth Factor in Head and Neck Cancer JF - Anticancer Research JO - Anticancer Res SP - 803 LP - 810 DO - 10.21873/anticanres.14832 VL - 41 IS - 2 AU - HUAI-PAO LEE AU - KUO-WANG TSAI AU - CHING-CHIH LEE Y1 - 2021/02/01 UR - http://ar.iiarjournals.org/content/41/2/803.abstract N2 - Background/Aim: We investigated the prognostic influence of both hepatoma-derived growth factor (HDGF) and p53 expression in head and neck cancer. Materials and Methods: HDGF and p53 immunostaining was scored based on staining intensities and percentage of tumor cells stained using tissue microarray composed of total 102 head and neck cancer samples. Results: Over-expression of HDGF and p53 was observed in cancer compared with adjacent normal tissues (p<0.001). In multivariate analyses, tumors with higher nuclear and cytoplasmic HDGF staining scores (p=0.019), and tumors with cN1-cN2 (compared with cN0) (p=0.014), were associated with worse overall survival. Conclusion: The increased expression of HDGF and p53 in the tumor compared with adjacent normal tissues could be a risk factor for tumorigenesis. Increased nuclear and cytoplasmic expression of HDGF, and cN staging correlated with overall survival and negatively influenced prognosis in head and neck cancer. ER -