PT  - JOURNAL ARTICLE
AU  - MASAHIRO SASAHARA
AU  - MITSURO KANDA
AU  - DAI SHIMIZU
AU  - CHIE TANAKA
AU  - YOSHIKUNI INOKAWA
AU  - NORIFUMI HATTORI
AU  - MASAMICHI HAYASHI
AU  - GORO NAKAYAMA
AU  - YASUHIRO KODERA
TI  - Tissue <em>RNFT2</em> Expression Levels Are Associated With Peritoneal Recurrence and Poor Prognosis in Gastric Cancer
AID  - 10.21873/anticanres.14812
DP  - 2021 Feb 01
TA  - Anticancer Research
PG  - 609--617
VI  - 41
IP  - 2
4099  - http://ar.iiarjournals.org/content/41/2/609.short
4100  - http://ar.iiarjournals.org/content/41/2/609.full
SO  - Anticancer Res2021 Feb 01; 41
AB  - Background/Aim: Disease recurrence is frequently observed after curative resection of advanced gastric cancer resulting in a poor prognosis. In the present study, we identified a candidate biomarker to predict recurrence and prognosis after curative resection of gastric cancer. Materials and Methods: A transcriptome analysis was conducted using surgically resected cancerous tissue from patients with metastatic gastric cancer to identify genes that are upregulated in primary and metastatic tissues. Results: Ring finger protein, transmembrane 2 (RNFT2) mRNA expression was upregulated in primary gastric cancer tissues and metastases compared with non-cancerous tissues. RNFT2 expression in gastric cancer cell lines was positively correlated with the EMT-related molecules GSC, MMP9, and RAC1. The RNFT2 high expression group exhibited a significantly shorter postoperative overall survival. Peritoneal recurrence was significantly higher in the RNFT2 high expression group. Conclusion: RNFT2 mRNA expression predicts peritoneal recurrence and is a potential prognostic biomarker for gastric cancer following curative gastrectomy.