PT  - JOURNAL ARTICLE
AU  - MORIKAZU MIYAMOTO
AU  - TAIRA HADA
AU  - HIROKI ISHIBASHI
AU  - HIDEKI IWAHASHI
AU  - SOICHIRO KAKIMOTO
AU  - RIE SUZUKI
AU  - TAKAHIRO SAKAMOTO
AU  - HIROKO MATSUURA
AU  - HITOSHI TSUDA
AU  - MASASHI TAKANO
TI  - A New Model to Improve the Prediction of Prognosis of Endometrial Carcinoma by Combining Traditional Classification With the Presence of Tumor-infiltrating Lymphocytes
AID  - 10.21873/anticanres.14861
DP  - 2021 Feb 01
TA  - Anticancer Research
PG  - 1047--1053
VI  - 41
IP  - 2
4099  - http://ar.iiarjournals.org/content/41/2/1047.short
4100  - http://ar.iiarjournals.org/content/41/2/1047.full
SO  - Anticancer Res2021 Feb 01; 41
AB  - Background/Aim: We aimed to predict the prognosis of endometrial carcinoma by combining traditional histological classification with the status of tumor-infiltrating lymphocytes (TILs). Patients and Methods: All patients with endometrial carcinoma, treated at our hospital, were classified into four categories—Category I: Type I positive for TILs; category II: type I negative for TILs; category III: type II positive for TILs; and category IV: type II negative for TILs. Prognoses were compared across all the categories. Positivity for TILs was defined as a continuously formed thick zone of TILs at the invasive front. Results: Multivariate analyses of progression-free and overall survival indicated that category classification was an independent prognostic factor, with hazard ratios of 3.127, 3.483, and 8.459 for progression-free survival, and 3.444, 4.374, and 11.058 for OS for patients in categories II, III, and IV, respectively. Conclusion: Combining traditional histological classification with TIL status might better predict prognosis of endometrial carcinoma.