PT  - JOURNAL ARTICLE
AU  - NAOKI YAMASHITA
AU  - TSUNEHIRO OYAMA
AU  - TETSUYA SO
AU  - TAKEAKI MIYATA
AU  - TAKASHI YOSHIMATSU
AU  - RYUJI NAKANO
AU  - WATARU MATSUNAGA
AU  - AKINOBU GOTOH
TI  - Association Between CD133 Expression and Prognosis in Human Lung Adenocarcinoma
AID  - 10.21873/anticanres.14843
DP  - 2021 Feb 01
TA  - Anticancer Research
PG  - 905--910
VI  - 41
IP  - 2
4099  - http://ar.iiarjournals.org/content/41/2/905.short
4100  - http://ar.iiarjournals.org/content/41/2/905.full
SO  - Anticancer Res2021 Feb 01; 41
AB  - Background/Aim: CD133 is a promising candidate marker for cancer stem cells. However, clinical studies on CD133 expression in human lung adenocarcinoma have not yet been conducted. We hypothesized that CD133 expression in lung adenocarcinoma is a poor prognostic factor. Patients and Methods: CD133 expression in lung adenocarcinoma was examined clinicopathologically. Then, clinicopathological parameters and patient prognosis were investigated. Moreover, CD133 expression was examined via immunohistochemical staining, and the relationship between CD133 expression and clinicopathological parameters was explored. Results: Approximately 48.0% (49/102) of patients had CD133-positive cells. Based on a subgroup analysis, the CD133-positive group with pStage I+II disease had a significantly worse disease-free interval than the CD133-negative group (p<0.05). Conclusion: CD133 expression may be a poor prognostic factor in lung adenocarcinoma.