RT Journal Article SR Electronic T1 Somatostatin Controls LFA-1 Gene Expression by Altering Neuraminidase Expression in Spleen Cells JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 2331 OP 2336 VO 24 IS 4 A1 YOON, WON-KEE A1 KIM, HO-JUN A1 SON, HWA-YOUNG A1 JEONG, KYU-SHIK A1 PARK, SANG-JOON A1 KIM, TAEHWAN A1 KIM, SUNG-HO A1 KIM, SE-RA A1 RYU, SI-YUN YR 2004 UL http://ar.iiarjournals.org/content/24/4/2331.abstract AB This study investigated whether neuraminidase (Neu) affects LFA-1 mRNA expression in spleen cells and whether somatostatin (SOM) and substance P (SP) treatment induce changes in the Neu mRNA expression level in spleen cells. Neu treatments down-regulated the LFA-1 mRNA levels after culturing for 2 h. SOM increased the Neu mRNA level slightly after 24-h culture and strongly after 48-h culture. These results suggest that prolonged exposure to SOM may regulate the Neu activation pathway, which in turn impairs the regulation of LFA-1 expression. Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved