PT  - JOURNAL ARTICLE
AU  - GRANT GODSMARK
AU  - LEONARDO ALVES DE SOUZA RIOS
AU  - SHAHEEN MOWLA
TI  - Activation-Induced Cytidine Deaminase Promotes Proliferation and Enhances Chemoresistance and Migration in B-cell Lymphoma
AID  - 10.21873/anticanres.14770
DP  - 2021 Jan 01
TA  - Anticancer Research
PG  - 237--247
VI  - 41
IP  - 1
4099  - http://ar.iiarjournals.org/content/41/1/237.short
4100  - http://ar.iiarjournals.org/content/41/1/237.full
SO  - Anticancer Res2021 Jan 01; 41
AB  - Background/Aim: Activation-induced cytidine deaminase (AID) is a DNA modifying enzyme which has an essential function in promoting antibody diversification. Its overexpression is strongly associated with B-cell derived malignancies including Burkitt lymphoma, where AID is required for the characteristic c-MYC/IGH translocation. This study aimed at defining AID’s oncopathogenic role which is still poorly understood. Materials and Methods: We created over-expressing and knock-down cell culture models of AID, and used cellular assays to provide insight into its contribution to lymphomagenesis. Results: We showed that AID expression is highly specific to, and abundantly expressed in B-cell-derived cancers and that ectopic overexpression of AID leads to rapid cell death. Using a knock-down model, we revealed that AID expression significantly impacts genomic stability, proliferation, migration and drug resistance. Conclusion: AID is an important driver of lymphoma, impacting multiple cellular events, and is potentially a strong candidate for targeted therapy in lymphoma.