PT  - JOURNAL ARTICLE
AU  - NORIO YAMAMOTO
AU  - MENG YANG
AU  - PING JIANG
AU  - MINGXU XU
AU  - KENSUKE YAMAUCHI
AU  - HIROYUKI TSUCHIYA
AU  - KATSURO TOMITA
AU  - A.R. MOOSSA
AU  - ROBERT M. HOFFMAN
TI  - Color Coding Cancer Cells with Fluorescent Proteins to Visualize <em>In Vivo</em> Cellular Interaction in Metastatic Colonies
DP  - 2004 Nov 01
TA  - Anticancer Research
PG  - 4067--4072
VI  - 24
IP  - 6
4099  - http://ar.iiarjournals.org/content/24/6/4067.short
4100  - http://ar.iiarjournals.org/content/24/6/4067.full
SO  - Anticancer Res2004 Nov 01; 24
AB  - We report here in vivo visualization of cancer cell interaction using stable sublines of green fluorescent protein (GFP)- and red fluorescent protein (RFP)-expressing HT-1080 human fibrosarcoma cells. These color-coded fibrosarcoma cell lines show similar cell proliferation and lung metastasis potential. The color-coded cells were mixed at a ratio of 1:1 and were injected into the tail vein of severe combined immunodeficient (SCID) mice. The resulting experimental lung metastases were simultaneously imaged and their ratio was determined by color-pixel analysis. Fluorescence color coding of cancer cells enables visualization of the interaction of cancer cells and can be used to distinguish cancer cells of any genotype or phenotype. Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved