RT Journal Article
SR Electronic
T1 Oncological Outcome and Prognostic Factors of Surgery for Soft Tissue Sarcoma After Neoadjuvant or Adjuvant Radiation Therapy: A Retrospective Analysis over 15 Years
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 359
OP 368
DO 10.21873/anticanres.14784
VO 41
IS 1
A1 HEINRICH M.L. MUEHLHOFER
A1 BENJAMIN SCHLOSSMACHER
A1 ULRICH LENZE
A1 FLORIAN LENZE
A1 RAINER BURGKART
A1 ALEXANDRA S. GERSING
A1 JAN C. PEEKEN
A1 STEPHANIE E. COMBS
A1 RUEDIGER VON EISENHART-ROTHE
A1 CAROLIN KNEBEL
YR 2021
UL http://ar.iiarjournals.org/content/41/1/359.abstract
AB Background/Aim: Surgical resection for soft tissue sarcomas (STSs) is the gold standard for a curative oncologic therapy in combination with neoadjuvant or adjuvant radiation therapy (NRT/ART). The aim of this study was to determine prognostic factors influencing the survival of patients with STS undergoing NRT or ART considering various parameters in a retrospective, single-centre analysis over 15 years. Patients and Methods: We included 119 patients (male 59) and the median follow-up period was 69 months (4-197). The patients received NRT (n=64) or ART (n=55). We recorded the histopathologic subtype of STS, tumour grade, localization, tumour margins, complications, survival, local recurrence, and metastases. Survival analysis was performed using the Kaplan–Meier method. Results: The overall survival rate was 68.9% at 5 years. The localization (epifascial/subfascial), resection margin and type of radiation therapy (NRT/ART) had no significant impact on survival. Tumour grade, tumour size, local recurrence and metastases were significantly correlated with patient survival (p<0.05). Local recurrence was significantly higher in patients with ART (p=0.044). Conclusion: Tumour grade and tumour size were independently associated with disease-specific survival, and patients with local recurrence and metastases had lower survival rates.