RT Journal Article
SR Electronic
T1 Combination of p53 and Ki67 as a Promising Predictor of Postoperative Recurrence of Meningioma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 203
OP 210
DO 10.21873/anticanres.14766
VO 41
IS 1
A1 ATSUFUMI NAGAHAMA
A1 MASAKAZU YASHIRO
A1 TOSHIYUKI KAWASHIMA
A1 KOSUKE NAKAJO
A1 HIROKI MORISAKO
A1 TAKEHIRO UDA
A1 KENTARO NAITO
A1 TSUTOMU ICHINOSE
A1 KENJI OHATA
A1 TAKEO GOTO
YR 2021
UL http://ar.iiarjournals.org/content/41/1/203.abstract
AB Background: Meningioma is a common intracranial tumor originating from arachnoid cap cells. Meningiomas are generally benign tumors curable by one-time resection. However, some meningiomas regrow and invade into the dura mater, and thus frequently require additional treatment. A useful marker to predict the regrowth of meningioma is desired. This study aimed to clarify the significance of p53 and Ki67 for postoperative recurrence of meningioma. Materials and Methods: The expression of p53 and Ki67 in 215 intracranial or intraspinal meningiomas was investigated by immunohistochemistry. Results: Of the 215 meningiomas, 35 cases (16.3%) were p53-positive and 49 cases (22.8%) were Ki67-positive. Multivariate analysis revealed Ki67 and p53 status as being significantly correlated with recurrence. Positivity for either Ki67- or p53 was significantly associated with poor recurrence-free survival. Conclusion: Combined p53 and Ki67 status might represent a useful independent predictive marker for recurrence of meningioma.