PT  - JOURNAL ARTICLE
AU  - ATSUFUMI NAGAHAMA
AU  - MASAKAZU YASHIRO
AU  - TOSHIYUKI KAWASHIMA
AU  - KOSUKE NAKAJO
AU  - HIROKI MORISAKO
AU  - TAKEHIRO UDA
AU  - KENTARO NAITO
AU  - TSUTOMU ICHINOSE
AU  - KENJI OHATA
AU  - TAKEO GOTO
TI  - Combination of p53 and Ki67 as a Promising Predictor of Postoperative Recurrence of Meningioma
AID  - 10.21873/anticanres.14766
DP  - 2021 Jan 01
TA  - Anticancer Research
PG  - 203--210
VI  - 41
IP  - 1
4099  - http://ar.iiarjournals.org/content/41/1/203.short
4100  - http://ar.iiarjournals.org/content/41/1/203.full
SO  - Anticancer Res2021 Jan 01; 41
AB  - Background: Meningioma is a common intracranial tumor originating from arachnoid cap cells. Meningiomas are generally benign tumors curable by one-time resection. However, some meningiomas regrow and invade into the dura mater, and thus frequently require additional treatment. A useful marker to predict the regrowth of meningioma is desired. This study aimed to clarify the significance of p53 and Ki67 for postoperative recurrence of meningioma. Materials and Methods: The expression of p53 and Ki67 in 215 intracranial or intraspinal meningiomas was investigated by immunohistochemistry. Results: Of the 215 meningiomas, 35 cases (16.3%) were p53-positive and 49 cases (22.8%) were Ki67-positive. Multivariate analysis revealed Ki67 and p53 status as being significantly correlated with recurrence. Positivity for either Ki67- or p53 was significantly associated with poor recurrence-free survival. Conclusion: Combined p53 and Ki67 status might represent a useful independent predictive marker for recurrence of meningioma.