PT  - JOURNAL ARTICLE
AU  - HIROKI KAWAGUCHI
AU  - YUSUKE DEMIZU
AU  - NARITOSHI MUKUMOTO
AU  - TAKEAKI ISHIHARA
AU  - DAISUKE MIYAWAKI
AU  - SHOHEI KOMATSU
AU  - HIROAKI AKASAKA
AU  - MAKOTO SHINOTO
AU  - YOSHIYUKI SHIOYAMA
AU  - KATSUMASA NAKAMURA
AU  - TAKUMI FUKUMOTO
AU  - RYOHEI SASAKI
TI  - Efficacy of Spacers in Radiation Therapy for Locally Advanced Pancreatic Cancer: A Planning Study
AID  - 10.21873/anticanres.14801
DP  - 2021 Jan 01
TA  - Anticancer Research
PG  - 503--508
VI  - 41
IP  - 1
4099  - http://ar.iiarjournals.org/content/41/1/503.short
4100  - http://ar.iiarjournals.org/content/41/1/503.full
SO  - Anticancer Res2021 Jan 01; 41
AB  - Background/Aim: We aimed to investigate the dosimetric effects of a spacer placed between the pancreas and surrounding gastrointestinal structures in intensity-modulated radiation therapy (IMRT) planning to provide more effective radiation therapy for locally advanced pancreatic cancer (LAPC). Patients and Methods: Treatment planning was performed for six patients with LAPC based on computed tomography images without spacers and with 5-mm or 10-mm spacers virtually inserted under the supervision of a hepatobiliary pancreatic surgeon. The prescription dose was 63 Gy in 28 fractions. Results: With the exception of one case of pancreatic head cancer, planning target volume receiving ≥95% of the prescribed dose (PTV V95) was achieved by 90% or more by inserting a spacer, and by 95% or more in all 3 cases of pancreatic body and tail cancer by inserting a 10-mm spacer. Conclusion: IMRT with appropriate spacer placement may help provide high-dose treatment for LAPC and improve associated patient outcomes.