PT - JOURNAL ARTICLE AU - AKIMITSU YAMADA AU - CHIHO SUZUKI AU - HIDETAKA SHIMA AU - KUMIKO KIDA AU - SHOKO ADACHI AU - SHINYA YAMAMOTO AU - KAZUTAKA NARUI AU - MIKIKO TANABE AU - DAISUKE SHIMIZU AU - RIE TANIGUCHI AU - MASANORI OSHI AU - KAZUAKI TAKABE AU - YOHEI MIYAGI AU - YASUSHI ICHIKAWA AU - TAKASHI ISHIKAWA AU - ITARU ENDO TI - Aldehyde Dehydrogenase 1-related Genes in Triple-negative Breast Cancer Investigated Using Network Analysis AID - 10.21873/anticanres.14696 DP - 2020 Dec 01 TA - Anticancer Research PG - 6733--6742 VI - 40 IP - 12 4099 - http://ar.iiarjournals.org/content/40/12/6733.short 4100 - http://ar.iiarjournals.org/content/40/12/6733.full SO - Anticancer Res2020 Dec 01; 40 AB - Background/Aim: Aldehyde dehydrogenase 1 (ALDH1) is known as a breast cancer stem cell (CSC) marker. This study aimed to identify genes associated with ALDH1. Materials and Methods: ALDH1-positive and -negative breast cancer cells were isolated using laser capture microdissection from five tissue samples of ALDH1-positive breast cancer patients. Messenger RNA expression levels were compared between ALDH1-positive and -negative cells. Results: We found 104 differentially expressed genes between ALDH1-positive and -negative cells. Gene ontology and pathway analysis revealed that these genes were correlated with CSC functions and pathways. Network analyses identified 10 genes that were closely associated with ALDH1. We validated these 10 genes utilizing The Cancer Genome Atlas and the Molecular Taxonomy of Breast Cancer International Consortium cohort, and found that they were associated with ALDH1 expression and correlated with Wnt pathway signaling. Conclusion: The 10 genes we identified could be potential targets for CSC therapy of breast cancer.