RT Journal Article SR Electronic T1 Outcome of Soft-tissue Reconstruction in the Setting of Combined Preoperative and Intraoperative Radiotherapy for Extremity Soft-tissue Sarcomas JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 6941 OP 6945 DO 10.21873/anticanres.14718 VO 40 IS 12 A1 RACHEL L. HONIG A1 MEAGAN E. TIBBO A1 KATHERINE E. MALLETT A1 KARIM BAKRI A1 SAFIA K. AHMED A1 IVY A. PETERSEN A1 PETER S. ROSE A1 STEVEN L. MORAN A1 MATTHEW T. HOUDEK YR 2020 UL http://ar.iiarjournals.org/content/40/12/6941.abstract AB Background/Aim: Reconstruction for soft-tissue sarcomas is complex and often uses soft-tissue flaps. To preserve critical structures, intraoperative radiotherapy (IORT) can be used to boost the total dose to these critical structures and close margins; however, there are limited data on the outcome of soft-tissue reconstruction in patients treated with IORT. Patients and Methods: Twenty patients received IORT with soft-tissue flap coverage. There were 14 tumors of the lower extremities and six of the upper, including seven free-flaps and 13 pedicle flaps. Mean preoperative and IORT doses were 49.4 Gy and 10.4 Gy, respectively, with a mean total dose of 59.8 Gy. Results: Seven (35%) patients had a complication, most commonly an infection (n=4, 27%). Total flap loss occurred in one treated with pedicle flap. Four (20%) patients suffered a radiation-associated fracture. At the final follow-up, the mean Musculoskeletal Tumor Society Score was 75±11%. Conclusion: Complications and postoperative fractures were common with IORT, however, there were no cases requiring amputation.