PT  - JOURNAL ARTICLE
AU  - HONIG, RACHEL L.
AU  - TIBBO, MEAGAN E.
AU  - MALLETT, KATHERINE E.
AU  - BAKRI, KARIM
AU  - AHMED, SAFIA K.
AU  - PETERSEN, IVY A.
AU  - ROSE, PETER S.
AU  - MORAN, STEVEN L.
AU  - HOUDEK, MATTHEW T.
TI  - Outcome of Soft-tissue Reconstruction in the Setting of Combined Preoperative and Intraoperative Radiotherapy for Extremity Soft-tissue Sarcomas
AID  - 10.21873/anticanres.14718
DP  - 2020 Dec 01
TA  - Anticancer Research
PG  - 6941--6945
VI  - 40
IP  - 12
4099  - http://ar.iiarjournals.org/content/40/12/6941.short
4100  - http://ar.iiarjournals.org/content/40/12/6941.full
SO  - Anticancer Res2020 Dec 01; 40
AB  - Background/Aim: Reconstruction for soft-tissue sarcomas is complex and often uses soft-tissue flaps. To preserve critical structures, intraoperative radiotherapy (IORT) can be used to boost the total dose to these critical structures and close margins; however, there are limited data on the outcome of soft-tissue reconstruction in patients treated with IORT. Patients and Methods: Twenty patients received IORT with soft-tissue flap coverage. There were 14 tumors of the lower extremities and six of the upper, including seven free-flaps and 13 pedicle flaps. Mean preoperative and IORT doses were 49.4 Gy and 10.4 Gy, respectively, with a mean total dose of 59.8 Gy. Results: Seven (35%) patients had a complication, most commonly an infection (n=4, 27%). Total flap loss occurred in one treated with pedicle flap. Four (20%) patients suffered a radiation-associated fracture. At the final follow-up, the mean Musculoskeletal Tumor Society Score was 75±11%. Conclusion: Complications and postoperative fractures were common with IORT, however, there were no cases requiring amputation.