TY - JOUR T1 - Hyperthermia During Intraperitoneal Chemotherapy With Paclitaxel or Docetaxel for Ovarian Cancer: Is There Any Benefit? JF - Anticancer Research JO - Anticancer Res SP - 6769 LP - 6780 DO - 10.21873/anticanres.14700 VL - 40 IS - 12 AU - EELCO DE BREE AU - DESPOINA KATSOUGKRI AU - HARA POLIOUDAKI AU - ELENA TSANGARIDOU AU - DIMOSTHENIS MICHELAKIS AU - ODYSSEAS ZORAS AU - PANAYIOTIS THEODOROPOULOS Y1 - 2020/12/01 UR - http://ar.iiarjournals.org/content/40/12/6769.abstract N2 - Background/aim: Intraperitoneal chemotherapy with taxanes provides high locoregional drug concentrations. Regarding their synergy with hyperthermia, results have been inconclusive. In this in vitro study, the thermal enhancement of the effect of paclitaxel and docetaxel on ovarian cancer cells under conditions mimicking those during hyperthermic intraperitoneal chemotherapy (HIPEC) is evaluated. Materials and Methods: Cisplatin-resistant SKOV-3 and OVCAR-3 ovarian cancer cells were exposed for 2 h to 0.1, 1 and 3 μΜ of paclitaxel and docetaxel at 37°C (normothermia) and 41.5°C (hyperthermia). Cell proliferation and cell-cycle distribution were evaluated after 24 h, 3 days and 7 days. Results: A concentration-dependent cytotoxic effect on cell proliferation was observed. Concurrent hyperthermia caused an increased arrest of cells in the G2/M phase. At 7 days, thermal enhancement of drug effect was shown only for treatment of OVCAR-3 cells with 1 μM paclitaxel. Conclusion: The concentration-dependent cytotoxic effect of paclitaxel and docetaxel supports their intraperitoneal use. Due to the lack of or only minimal thermal enhancement, normothermic may be as effective as hyperthermic intraoperative intraperitoneal chemotherapy with taxanes, avoiding, however, potential oncological and treatment-related adverse effects of concurrent hyperthermia. ER -