TY - JOUR T1 - Stage III and Metastatic Lymph Node Ratio Are the only Independent Prognostic Factors in Colorectal Signet-ring Cell Carcinoma Patients JF - Anticancer Research JO - Anticancer Res SP - 7127 LP - 7134 DO - 10.21873/anticanres.14742 VL - 40 IS - 12 AU - ALFREDO ANNICCHIARICO AU - ANDREA MORINI AU - ANDREA ROMBOLI AU - MATTEO RICCÒ AU - FRANCESCO LEONARDI AU - PELLEGRINO CRAFA AU - EDOARDO VIRGILIO AU - PAOLO DELL’ABATE AU - RENATO COSTI Y1 - 2020/12/01 UR - http://ar.iiarjournals.org/content/40/12/7127.abstract N2 - Background/Aim: Signet-ring cell carcinoma (SRCC) is an uncommon histological variant of colorectal cancer (CRC). Knowledge is scarce due to its rarity. Our aim was to better evaluate the clinicopathologic and prognostic features of this little-known malignancy. Patients and Methods: Thirty-nine consecutive patients with non-metastatic colorectal SRCC undergoing curative resection at University Hospital of Parma between 2000 and 2018 were examined in this retrospective analysis. Results: Mean overall (OS) and disease-free survival (DFS) were 33.6 and 31.5 months, respectively. At univariate analysis, the lymph-related parameters (nodal status, Stage III, metastatic lymph node ratio and lymphovascular invasion) were significantly associated with shorter OS and poorer DFS. At multivariate analysis, Stage III and a metastatic lymph node ratio ≥25% were found to be the only independent prognostic factors significantly correlated with worse OS and DFS. Conclusion: Nodal and lymphatic status should be carefully pondered when planning the most appropriate management of patients with colorectal SRCC. ER -