RT Journal Article
SR Electronic
T1 Stage III and Metastatic Lymph Node Ratio Are the only Independent Prognostic Factors in Colorectal Signet-ring Cell Carcinoma Patients
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 7127
OP 7134
DO 10.21873/anticanres.14742
VO 40
IS 12
A1 ALFREDO ANNICCHIARICO
A1 ANDREA MORINI
A1 ANDREA ROMBOLI
A1 MATTEO RICCÒ
A1 FRANCESCO LEONARDI
A1 PELLEGRINO CRAFA
A1 EDOARDO VIRGILIO
A1 PAOLO DELL’ABATE
A1 RENATO COSTI
YR 2020
UL http://ar.iiarjournals.org/content/40/12/7127.abstract
AB Background/Aim: Signet-ring cell carcinoma (SRCC) is an uncommon histological variant of colorectal cancer (CRC). Knowledge is scarce due to its rarity. Our aim was to better evaluate the clinicopathologic and prognostic features of this little-known malignancy. Patients and Methods: Thirty-nine consecutive patients with non-metastatic colorectal SRCC undergoing curative resection at University Hospital of Parma between 2000 and 2018 were examined in this retrospective analysis. Results: Mean overall (OS) and disease-free survival (DFS) were 33.6 and 31.5 months, respectively. At univariate analysis, the lymph-related parameters (nodal status, Stage III, metastatic lymph node ratio and lymphovascular invasion) were significantly associated with shorter OS and poorer DFS. At multivariate analysis, Stage III and a metastatic lymph node ratio ≥25% were found to be the only independent prognostic factors significantly correlated with worse OS and DFS. Conclusion: Nodal and lymphatic status should be carefully pondered when planning the most appropriate management of patients with colorectal SRCC.