PT  - JOURNAL ARTICLE
AU  - GUNEL GULIYEVA
AU  - MARIA T. HUAYLLANI
AU  - FRANCISCO R. AVILA
AU  - DANIEL BOCZAR
AU  - XIAONA LU
AU  - ANTONIO JORGE FORTE
TI  - Younger Age as a Risk Factor for Gynecologic Cancer–related Lymphedema: A Systematic Review
AID  - 10.21873/anticanres.14685
DP  - 2020 Dec 01
TA  - Anticancer Research
PG  - 6609--6612
VI  - 40
IP  - 12
4099  - http://ar.iiarjournals.org/content/40/12/6609.short
4100  - http://ar.iiarjournals.org/content/40/12/6609.full
SO  - Anticancer Res2020 Dec 01; 40
AB  - Background/Aim: Treatment of gynecologic cancers may lead to the development of lower limb lymphedema. As the course of lymphedema is chronic and progressive, early diagnosis plays a significant role in decreasing morbidity. Therefore, risk assessment is of utmost importance. In this study, we aimed to investigate the impact of age on lymphedema development after treatment for gynecologic cancers. Materials and Methods: The search of 3 databases (PubMed, Scopus, and Cochrane) revealed 7 relevant articles, which reported either odds ratios or hazard ratios as an outcome measure. Results: A positive relationship between younger age and lower limb lymphedema was shown by 3 articles, while 2 noted increased incidence with older age. The remaining articles reported no significant relationship. Conclusion: Younger age is a risk factor for gynecologic cancer–related lymphedema. However, as individual studies have not included all types of gynecologic cancers, results may not be generalizable.