TY - JOUR T1 - Biweekly Cabazitaxel Is a Safe Treatment Option for Metastatic Castration-resistant Prostate Cancer (mCRPC) Patients After Docetaxel – A Final Analysis of the Prosty II Trial JF - Anticancer Research JO - Anticancer Res SP - 6915 LP - 6921 DO - 10.21873/anticanres.14715 VL - 40 IS - 12 AU - PIRKKO-LIISA KELLOKUMPU-LEHTINEN AU - TIMO MARTTILA AU - ANTTI JEKUNEN AU - PETTERI HERVONEN AU - KATARIINA KLINTRUP AU - VESA KATAJA AU - TAPIO UTRIAINEN AU - MARJAANA LUUKKAA AU - MARKKU LESKINEN AU - KALEVI PULKKANEN AU - ANNA-LIISA KAUTIO AU - TEPPO HUTTUNEN Y1 - 2020/12/01 UR - http://ar.iiarjournals.org/content/40/12/6915.abstract N2 - Background/Aim: Our phase III trial showed that biweekly docetaxel (D) is better tolerated than triweekly D in metastatic castration-resistant prostate cancer (mCRPC). The safety of biweekly cabazitaxel (CBZ) post-docetaxel was studied in mCRPC. Patients and Methods: Altogether, 60 patients received CBZ 16 mg/m2 i.v. on day 1 and day 14 of a 4-week cycle. The mean serum PSA levels were 305 ng/ml, and the mean age 67 years. The primary endpoint was safety according to CTCAEv4.0. Results: A total of 255 4-week cycles of CBZ were administered. The most common grade 3/4 adverse events were neutropenia (16.7%), pain (13.3%), fatigue (10.0%), anemia (5.0%) and non-neutropenic infection (10.0%). PSA responses occurred in 10 patients (16.7%). Clinical benefit rate was 38.3% and median survival 10 months. Conclusion: Biweekly CBZ is a well-tolerated treatment resulting in meaningful benefits for heavily pretreated mCRPC patients. ER -