<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">KELLOKUMPU-LEHTINEN, PIRKKO-LIISA</style></author><author><style face="normal" font="default" size="100%">MARTTILA, TIMO</style></author><author><style face="normal" font="default" size="100%">JEKUNEN, ANTTI</style></author><author><style face="normal" font="default" size="100%">HERVONEN, PETTERI</style></author><author><style face="normal" font="default" size="100%">KLINTRUP, KATARIINA</style></author><author><style face="normal" font="default" size="100%">KATAJA, VESA</style></author><author><style face="normal" font="default" size="100%">UTRIAINEN, TAPIO</style></author><author><style face="normal" font="default" size="100%">LUUKKAA, MARJAANA</style></author><author><style face="normal" font="default" size="100%">LESKINEN, MARKKU</style></author><author><style face="normal" font="default" size="100%">PULKKANEN, KALEVI</style></author><author><style face="normal" font="default" size="100%">KAUTIO, ANNA-LIISA</style></author><author><style face="normal" font="default" size="100%">HUTTUNEN, TEPPO</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Biweekly Cabazitaxel Is a Safe Treatment Option for Metastatic Castration-resistant Prostate Cancer (mCRPC) Patients After Docetaxel – A Final Analysis of the Prosty II Trial</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2020-12-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">6915-6921</style></pages><doi><style  face="normal" font="default" size="100%">10.21873/anticanres.14715</style></doi><volume><style face="normal" font="default" size="100%">40</style></volume><issue><style face="normal" font="default" size="100%">12</style></issue><abstract><style  face="normal" font="default" size="100%">Background/Aim: Our phase III trial showed that biweekly docetaxel (D) is better tolerated than triweekly D in metastatic castration-resistant prostate cancer (mCRPC). The safety of biweekly cabazitaxel (CBZ) post-docetaxel was studied in mCRPC. Patients and Methods: Altogether, 60 patients received CBZ 16 mg/m2 i.v. on day 1 and day 14 of a 4-week cycle. The mean serum PSA levels were 305 ng/ml, and the mean age 67 years. The primary endpoint was safety according to CTCAEv4.0. Results: A total of 255 4-week cycles of CBZ were administered. The most common grade 3/4 adverse events were neutropenia (16.7%), pain (13.3%), fatigue (10.0%), anemia (5.0%) and non-neutropenic infection (10.0%). PSA responses occurred in 10 patients (16.7%). Clinical benefit rate was 38.3% and median survival 10 months. Conclusion: Biweekly CBZ is a well-tolerated treatment resulting in meaningful benefits for heavily pretreated mCRPC patients.</style></abstract></record></records></xml>