%0 Journal Article %A CHUNG-LIN TSAI %A CHIA-WEN TSAI %A WEN-SHIN CHANG %A CHEN-HSIEN SU %A LIANG-CHIH LIU %A HWEI-CHUNG WANG %A HSU-TUNG LEE %A CHUN-MING YEN %A JAW-CHYUN CHEN %A YUN-CHI WANG %A CHAO-HSUAN CHEN %A DA-TIAN BAU %T Interleukin-13 Promoter Genotypes and Taiwanese Breast Cancer Susceptibility %D 2020 %R 10.21873/anticanres.14697 %J Anticancer Research %P 6743-6749 %V 40 %N 12 %X Background/Aim: The current study aimed at evaluating the contribution of IL-13 promoter rs1881457 and rs1800925 genotypes to the risk of breast cancer in Taiwan. Materials and Methods: A total of 1,232 breast cancer cases and 1,232 age-matched controls were genotyped by typical polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. Results: As for IL-13 rs1881457, the rates of AA, AC and CC genotypes were 54.8, 37.9 and 7.3% among the cases, and 53.8, 38.7 and 7.5% among the healthy controls, respectively; there were no statistically significant differences between the two groups (p for trend=0.8889). Also, regarding IL-13 rs1800925, there were no statistically significant differences between the two groups either (p for trend=0.6803). Furthermore, the allelic frequencies for IL-13 rs1881457 and rs1800925 were not differentially distributed between the case and control groups (p=0.6515 and 0.8753, respectively). Conclusion: The rs1881457 and rs1800925 IL-13 promoter polymorphisms may not serve as breast cancer susceptibility determinants for Taiwanese. %U https://ar.iiarjournals.org/content/anticanres/40/12/6743.full.pdf